Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone

Variations within proteasome β (PSMB) genes, which encode the β subunits of the 20S proteasome, may affect proteasome function, assembly, and/or binding of proteasome inhibitors. To investigate the potential association between PSMB gene variants and treatment-emergent resistance to bortezomib and/o...

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Detalhes bibliográficos
Main Authors: Lichter, David I., Danaee, Hadi, Pickard, Michael D., Tayber, Olga, Sintchak, Michael, Shi, Hongliang, Richardson, Paul G., Cavenagh, Jamie, Bladé, Joan, Façon, Thierry, Niesvizky, Ruben, Alsina, Melissa, Dalton, William, Sonneveld, Pieter, Lonial, Sagar, van de Velde, Helgi, Ricci, Deborah, Esseltine, Dixie-Lee, Trepicchio, William L., Mulligan, George, Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757460/
https://ncbi.nlm.nih.gov/pubmed/23018640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-426924
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