Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone

Variations within proteasome β (PSMB) genes, which encode the β subunits of the 20S proteasome, may affect proteasome function, assembly, and/or binding of proteasome inhibitors. To investigate the potential association between PSMB gene variants and treatment-emergent resistance to bortezomib and/o...

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Hauptverfasser: Lichter, David I., Danaee, Hadi, Pickard, Michael D., Tayber, Olga, Sintchak, Michael, Shi, Hongliang, Richardson, Paul G., Cavenagh, Jamie, Bladé, Joan, Façon, Thierry, Niesvizky, Ruben, Alsina, Melissa, Dalton, William, Sonneveld, Pieter, Lonial, Sagar, van de Velde, Helgi, Ricci, Deborah, Esseltine, Dixie-Lee, Trepicchio, William L., Mulligan, George, Anderson, Kenneth C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Clinical Trials and Observations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757460/
https://ncbi.nlm.nih.gov/pubmed/23018640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-426924
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