Loss of NPC1 function in a patient with a co-inherited novel insulin receptor mutation does not grossly modify the severity of the associated insulin resistance

In Npc1 null mice, a model for Niemann Pick Disease Type C1, it has been reported that hepatocyte insulin receptor function is significantly impaired, consistent with growing evidence that membrane fluidity and microdomain structure have an important role in insulin signal transduction. However, whe...

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Bibliographic Details
Main Authors: Kirk, J., Porter, K. M., Parker, V., Barroso, I., O’Rahilly, S., Hendriksz, C., Semple, R. K.
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2010
Subjects:
Case Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757264/
https://ncbi.nlm.nih.gov/pubmed/20521171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-010-9107-5
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