Pharmacological targeting of the PI3K/mTOR pathway alters the release of angioregulatory mediators both from primary human acute myeloid leukemia cells and their neighboring stromal cells

Acute myeloid leukemia (AML) is a heterogeneous and aggressive malignancy with poor overall survival. Constitutive as well as cytokine-initiated activation of PI3K/Akt/mTOR signaling is a common feature of AML patients, and inhibition of this pathway is considered as a possible therapeutic strategy...

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Bibliografske podrobnosti
Main Authors: Reikvam, Håkon, Nepstad, Ina, Bruserud, Øystein, Hatfield, Kimberley Joanne
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2013
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757241/
https://ncbi.nlm.nih.gov/pubmed/23919981
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