Peroxisome Proliferator-activated Receptor γ (PPARγ) and Its Target Genes Are Downstream Effectors of FoxO1 Protein in Islet β-Cells: MECHANISM OF β-CELL COMPENSATION AND FAILURE

The molecular mechanisms and signaling pathways that drive islet β-cell compensation and failure are not fully resolved. We have used in vitro and in vivo systems to show that FoxO1, an integrator of metabolic stimuli, inhibits PPARγ expression in β-cells, thus transcription of its target genes (Pdx...

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Bibliographische Detailangaben
Hauptverfasser: Gupta, Dhananjay, Leahy, Averi A., Monga, Navjot, Peshavaria, Mina, Jetton, Thomas L., Leahy, Jack L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757206/
https://ncbi.nlm.nih.gov/pubmed/23788637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.486852
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