Physiologic and Pharmacologic Modulation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Expression in β-Cells by Peroxisome Proliferator–Activated Receptor (PPAR)-γ Signaling: Possible Mechanism for the GIP Resistance in Type 2 Diabetes

OBJECTIVE: We previously showed that peroxisome proliferator–activated receptor (PPAR)-γ in β-cells regulates pdx-1 transcription through a functional PPAR response element (PPRE). Gene Bank blast for a homologous nucleotide sequence revealed the same PPRE within the rat glucose-dependent insulinotr...

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Detalhes bibliográficos
Main Authors: Gupta, Dhananjay, Peshavaria, Mina, Monga, Navjot, Jetton, Thomas L., Leahy, Jack L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874705/
https://ncbi.nlm.nih.gov/pubmed/20332343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1655
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