FcγR-driven Release of IL-6 by Macrophages Requires NOX2-dependent Production of Reactive Oxygen Species

Activation of the FcγR via antigen containing immune complexes can lead to the generation of reactive oxygen species, which are potent signal transducing molecules. However, whether ROS contribute to FcγR signaling has not been studied extensively. We set out to elucidate the role of NADPH oxidase-g...

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Autores principales: Franchini, Anthony M., Hunt, Danielle, Melendez, J. Andres, Drake, James R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757174/
https://ncbi.nlm.nih.gov/pubmed/23857584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.474106
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