The Individualized Genetic Barrier Predicts Treatment Response in a Large Cohort of HIV-1 Infected Patients

The success of combination antiretroviral therapy is limited by the evolutionary escape dynamics of HIV-1. We used Isotonic Conjunctive Bayesian Networks (I-CBNs), a class of probabilistic graphical models, to describe this process. We employed partial order constraints among viral resistance mutati...

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Detalhes bibliográficos
Main Authors: Beerenwinkel, Niko, Montazeri, Hesam, Schuhmacher, Heike, Knupfer, Patrick, von Wyl, Viktor, Furrer, Hansjakob, Battegay, Manuel, Hirschel, Bernard, Cavassini, Matthias, Vernazza, Pietro, Bernasconi, Enos, Yerly, Sabine, Böni, Jürg, Klimkait, Thomas, Cellerai, Cristina, Günthard, Huldrych F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757085/
https://ncbi.nlm.nih.gov/pubmed/24009493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003203
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