Aging-Induced Collateral Dysfunction: Impaired Responsiveness of Collaterals and Susceptibility to Apoptosis via Dysfunctional eNOS signaling

Despite positive animal studies, clinical angiogenesis trials have been disappointing, possibly due to risk factors present in humans but usually unexplored in animals. We recently demonstrated aging causes impaired collateral remodeling and collateral dropout; here, we investigate potential mechani...

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Bibliografiske detaljer
Main Authors: Wang, Jinsong, Peng, XinZhi, Lassance-Soares, Roberta M., Najafi, Amir H., Alderman, Lee O., Sood, Subeena, Xue, Zhenyi, Chan, Rosanna, Faber, James E., Epstein, Stephen E., Burnett, Mary Susan
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756560/
https://ncbi.nlm.nih.gov/pubmed/21538183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12265-011-9280-4
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