Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel small molecule Hypoxia Inducible Factor-1 (HIF-1) pathway inhibitors and anti-cancer agents

The Hypoxia Inducible Factor (HIF) pathway is an attractive target for cancer as it controls tumor adaptation to growth under hypoxia and mediates chemo- and radiation resistance. We previously discovered 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, as a novel s...

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Bibliographische Detailangaben
Hauptverfasser: Mun, Jiyoung, Jabbar, Adnan Abdul, Devi, Narra Sarojini, Yin, Shaoman, Wang, Yingzhe, Tan, Chalet, Culver, Deborah, Snyder, James P., Van Meir, Erwin G., Goodman, Mark M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756490/
https://ncbi.nlm.nih.gov/pubmed/22746274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300752n
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