Vaxfectin-adjuvanted plasmid DNA vaccine improves protection and immunogenicity in a murine model of genital herpes infection

The herpes simplex type 2 (HSV-2) envelope glycoprotein (gD2) was evaluated as a potential antigen candidate for a plasmid DNA (pDNA)-based HSV-2 vaccine. The pDNA was formulated with Vaxfectin, a cationic lipid-based adjuvant, and tested in a murine HSV-2 lethal challenge model. gD2 was expressed a...

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Main Authors: Shlapobersky, Mark, Marshak, Joshua O., Dong, Lichun, Huang, Meei-li, Wei, Qun, Chu, Alice, Rolland, Alain, Sullivan, Sean, Koelle, David M.
格式: Artigo
語言:Inglês
出版: Society for General Microbiology 2012
主題:
Animal
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755514/
https://ncbi.nlm.nih.gov/pubmed/22398318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.040055-0
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