Intracellular Targets for a Phosphotyrosine Peptidomimetic include the Mitotic Kinesin, MCAK

SH2 domains are attractive targets for chemotherapeutic agents due to their involvement in the formation of protein-protein interactions critical to many signal transduction cascades. Little is known, however, about how synthetic SH2 domain ligands would influence the growth properties of tumor cell...

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Autores principales: Huang, Rong, Oh, Hyunju, Arrendale, Allison, Martin, Victoria A., Galan, Jacob, Workman, Eric J., Stout, Jane R., Walczak, Claire E., Tao, W. Andy, Borch, Richard F., Geahlen, Robert L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755495/
https://ncbi.nlm.nih.gov/pubmed/23830822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.06.024
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