An Attenuated Cytomegalovirus Vaccine with a Deletion of a Viral Chemokine Gene Is Protective against Congenital CMV Transmission in a Guinea Pig Model

Development of a vaccine against congenital cytomegalovirus (CMV) infection is a public health priority, but CMVs encode immune evasion genes that complicate live virus vaccine design. To resolve this problem, this study employed guanosyl phosphoribosyl transferase (gpt) mutagenesis to generate a re...

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Detalhes bibliográficos
Main Authors: Leviton, Michael P., Lacayo, Juan C., Choi, K. Yeon, Hernandez-Alvarado, Nelmary, Wey, Andrew, Schleiss, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755440/
https://ncbi.nlm.nih.gov/pubmed/24000289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/906948
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