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Intratumoral Modeling of Gefitinib Pharmacokinetics and Pharmacodynamics in an Orthotopic Mouse Model of Glioblastoma
Like many solid tumors, glioblastomas are characterized by intratumoral biological heterogeneity that may contribute to a variable distribution of drugs and their associated pharmacodynamics (PD) responses, such that that standard pharmacokinetic (PK) approaches based on analysis of whole tumor homo...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3755354/ https://ncbi.nlm.nih.gov/pubmed/23796561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0690 |
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