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Demonstration of the Equivalent Pharmacokinetic/Pharmacodynamic Dosing Strategy in a Multiple-Dose Study of Gefitinib
The goals of this investigation were to illustrate the use of pharmacokinetic (PK)/pharmacodynamic (PD) modeling strategies in drug development based on a multiple-dose study of gefitinib in a preclinical tumor model. Mice bearing subcutaneous LN229-wild-type EGFR or LN229-EGFRvIII mutant (a sensiti...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862725/ https://ncbi.nlm.nih.gov/pubmed/19509243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0089 |
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