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Demonstration of the Equivalent Pharmacokinetic/Pharmacodynamic Dosing Strategy in a Multiple-Dose Study of Gefitinib

The goals of this investigation were to illustrate the use of pharmacokinetic (PK)/pharmacodynamic (PD) modeling strategies in drug development based on a multiple-dose study of gefitinib in a preclinical tumor model. Mice bearing subcutaneous LN229-wild-type EGFR or LN229-EGFRvIII mutant (a sensiti...

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Bibliografiske detaljer
Main Authors: Wang, Shining, Zhou, Qingyu, Gallo, James M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862725/
https://ncbi.nlm.nih.gov/pubmed/19509243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0089
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