Agglomerated Oral Dosage Forms of Artemisinin/β-Cyclodextrin Spray-Dried Primary Microparticles Showing Increased Dissolution Rate and Bioavailability

Artemisinin, a poorly water-soluble antimalarial drug, presents a low and erratic bioavailability upon oral administration. The aim of this work was to study an agglomerated powder dosage form for oral administration of artemisinin based on the artemisinin/β-cyclodextrin primary microparticles. Thes...

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Detalhes bibliográficos
Main Authors: Balducci, Anna Giulia, Magosso, Enrico, Colombo, Gaia, Sonvico, Fabio, Khan, Nurzalina Abdul Karim, Yuen, Kah Hay, Bettini, Ruggero, Colombo, Paolo, Rossi, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755174/
https://ncbi.nlm.nih.gov/pubmed/23703233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-013-9982-9
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