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Quality by Design: Scale-Up of Freeze-Drying Cycles in Pharmaceutical Industry
This paper shows the application of mathematical modeling to scale-up a cycle developed with lab-scale equipment on two different production units. The above method is based on a simplified model of the process parameterized with experimentally determined heat and mass transfer coefficients. In this...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3755168/ https://ncbi.nlm.nih.gov/pubmed/23884856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-013-0003-9 |
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