Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A

Hookworms are parasitic nematodes that have a devastating impact on global health, particularly in developing countries. We report a biochemical and structural analysis of a peroxiredoxin from the hookworm Ancylostoma ceylanicum, AcePrx-1. Peroxiredoxins provide antioxidant protection and act as sig...

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Hauptverfasser: Nguyen, Jennifer B., Pool, Christopher D., Wong, Christina Y.B., Treger, Rebecca S., Williams, David L., Cappello, Michael, Lea, Wendy A., Simeonov, Anton, Vermeire, Jon J., Modis, Yorgo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755041/
https://ncbi.nlm.nih.gov/pubmed/23891152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.06.011
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