DNA repair genes are selectively mutated in diffuse large B cell lymphomas

DNA repair mechanisms are fundamental for B cell development, which relies on the somatic diversification of the immunoglobulin genes by V(D)J recombination, somatic hypermutation, and class switch recombination. Their failure is postulated to promote genomic instability and malignant transformation...

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Huvudupphovsmän: de Miranda, Noel FCC, Peng, Roujun, Georgiou, Konstantinos, Wu, Chenglin, Sörqvist, Elin Falk, Berglund, Mattias, Chen, Longyun, Gao, Zhibo, Lagerstedt, Kristina, Lisboa, Susana, Roos, Fredrik, van Wezel, Tom, Teixeira, Manuel R., Rosenquist, Richard, Sundström, Christer, Enblad, Gunilla, Nilsson, Mats, Zeng, Yixin, Kipling, David, Pan-Hammarström, Qiang
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754869/
https://ncbi.nlm.nih.gov/pubmed/23960188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122842
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