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DNA repair genes are selectively mutated in diffuse large B cell lymphomas
DNA repair mechanisms are fundamental for B cell development, which relies on the somatic diversification of the immunoglobulin genes by V(D)J recombination, somatic hypermutation, and class switch recombination. Their failure is postulated to promote genomic instability and malignant transformation...
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Main Authors: | , , , , , , , , , , , , , , , , , , , |
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格式: | Artigo |
語言: | Inglês |
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The Rockefeller University Press
2013
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在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3754869/ https://ncbi.nlm.nih.gov/pubmed/23960188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122842 |
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