DNA repair genes are selectively mutated in diffuse large B cell lymphomas

DNA repair mechanisms are fundamental for B cell development, which relies on the somatic diversification of the immunoglobulin genes by V(D)J recombination, somatic hypermutation, and class switch recombination. Their failure is postulated to promote genomic instability and malignant transformation...

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Main Authors: de Miranda, Noel FCC, Peng, Roujun, Georgiou, Konstantinos, Wu, Chenglin, Sörqvist, Elin Falk, Berglund, Mattias, Chen, Longyun, Gao, Zhibo, Lagerstedt, Kristina, Lisboa, Susana, Roos, Fredrik, van Wezel, Tom, Teixeira, Manuel R., Rosenquist, Richard, Sundström, Christer, Enblad, Gunilla, Nilsson, Mats, Zeng, Yixin, Kipling, David, Pan-Hammarström, Qiang
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2013
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754869/
https://ncbi.nlm.nih.gov/pubmed/23960188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122842
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