Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

Treatment with monoclonal antibody specific for cytotoxic T lymphocyte–associated antigen 4 (CTLA-4), an inhibitory receptor expressed by T lymphocytes, has emerged as an effective therapy for the treatment of metastatic melanoma. Although subject to debate, current models favor a mechanism of activ...

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Autori principali: Simpson, Tyler R., Li, Fubin, Montalvo-Ortiz, Welby, Sepulveda, Manuel A., Bergerhoff, Katharina, Arce, Frederick, Roddie, Claire, Henry, Jake Y., Yagita, Hideo, Wolchok, Jedd D., Peggs, Karl S., Ravetch, Jeffrey V., Allison, James P., Quezada, Sergio A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754863/
https://ncbi.nlm.nih.gov/pubmed/23897981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130579
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