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PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

Vaccination with irradiated B16 melanoma cells expressing either GM-CSF (Gvax) or Flt3-ligand (Fvax) combined with antibody blockade of the negative T-cell costimulatory receptor cytotoxic T-lymphocyte antigen-4 (CTLA-4) promotes rejection of preimplanted tumors. Despite CTLA-4 blockade, T-cell prol...

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Bibliografiske detaljer
Main Authors: Curran, Michael A., Montalvo, Welby, Yagita, Hideo, Allison, James P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840093/
https://ncbi.nlm.nih.gov/pubmed/20160101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915174107
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