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In the Absence of RidA, Endogenous 2-Aminoacrylate Inactivates Alanine Racemases by Modifying the Pyridoxal 5′-Phosphate Cofactor
Members of the RidA (YjgF/YER057c/UK114) protein family are broadly conserved across the domains of life. In vitro, these proteins deaminate 3- or 4-carbon enamines that are generated as mechanistic intermediates of pyridoxal 5′-phosphate (PLP)-dependent serine/threonine dehydratases. The three-carb...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3754577/ https://ncbi.nlm.nih.gov/pubmed/23749972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00463-13 |
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