Učitavanje...
Unshackling caspase-7 for cancer therapy
Numerous solid tumors and hematologic malignancies acquire resistance to apoptosis-inducing chemotherapeutic drugs by downregulating the key effector caspase-3. These cells rely on caspase-7 to execute the apoptotic program, yet binding with XIAP constitutively inhibits active caspase-7 (p19/p12-CAS...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3754280/ https://ncbi.nlm.nih.gov/pubmed/23979156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71440 |
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