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Unshackling caspase-7 for cancer therapy

Numerous solid tumors and hematologic malignancies acquire resistance to apoptosis-inducing chemotherapeutic drugs by downregulating the key effector caspase-3. These cells rely on caspase-7 to execute the apoptotic program, yet binding with XIAP constitutively inhibits active caspase-7 (p19/p12-CAS...

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Bibliografische gegevens
Hoofdauteurs: Guicciardi, Maria Eugenia, Gores, Gregory J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754280/
https://ncbi.nlm.nih.gov/pubmed/23979156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71440
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