Targeting the XIAP/caspase-7 complex selectively kills caspase-3–deficient malignancies

Caspase-3 downregulation (CASP3/DR) in tumors frequently confers resistance to cancer therapy and is significantly correlated with a poor prognosis in cancer patients. Because CASP3/DR cancer cells rely heavily on the activity of caspase-7 (CASP7) to initiate apoptosis, inhibition of activated CASP7...

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Main Authors: Lin, Yuan-Feng, Lai, Tsung-Ching, Chang, Chih-Kang, Chen, Chi-Long, Huang, Ming-Shyan, Yang, Chih-Jen, Liu, Hon-Ge, Dong, Jhih-Jhong, Chou, Yi-An, Teng, Kuo-Hsun, Chen, Shih-Hsun, Tian, Wei-Ting, Jan, Yi-Hua, Hsiao, Michael, Liang, Po-Huang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754255/
https://ncbi.nlm.nih.gov/pubmed/23979166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67951
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