Mapping the Structural Determinants Responsible for Enhanced T Cell Activation to the Immunogenic Adeno-Associated Virus Capsid from Isolate Rhesus 32.33

Avoiding activation of immunity to vector-encoded proteins is critical to the safe and effective use of adeno-associated viral (AAV) vectors for gene therapy. While commonly used serotypes, such as AAV serotypes 1, 2, 7, 8, and 9, are often associated with minimal and/or dysfunctional CD8(+) T cell...

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Main Authors: Mays, Lauren E., Wang, Lili, Tenney, Rebeca, Bell, Peter, Nam, Hyun-Joo, Lin, Jianping, Gurda, Brittney, Van Vliet, Kim, Mikals, Kyle, Agbandje-McKenna, Mavis, Wilson, James M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754105/
https://ncbi.nlm.nih.gov/pubmed/23720715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00596-13
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