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The Membrane-Proximal “Stem” Region Increases the Stability of the Flavivirus E Protein Postfusion Trimer and Modulates Its Structure

The flavivirus fusion protein E contains a “stem” region which is hypothesized to be crucial for driving fusion. This sequence element connects the ectodomain to the membrane anchor, and its structure in the trimeric postfusion conformation is still poorly defined. Using E trimers of tick-borne ence...

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Bibliografske podrobnosti
Main Authors: Stiasny, Karin, Kiermayr, Stefan, Bernhart, Andrea, Heinz, Franz X.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754098/
https://ncbi.nlm.nih.gov/pubmed/23804648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01283-13
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