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A Cholesterol Tag at the N Terminus of the Relatively Broad-Spectrum Fusion Inhibitory Peptide Targets an Earlier Stage of Fusion Glycoprotein Activation and Increases the Peptide's Antiviral Potency In Vivo

In previous work, we designed peptides that showed potent inhibition of Newcastle disease virus (NDV) and infectious bronchitis virus (IBV) infections in chicken embryos. In this study, we demonstrate that peptides modified with cholesterol or 3 U of polyethylene glycol (PEG(3)) conjugated to the pe...

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Bibliografiske detaljer
Main Authors: Li, Chuan-Gen, Tang, Wang, Chi, Xiao-Jing, Dong, Zhi-Ming, Wang, Xi-Xi, Wang, Xiao-Jia
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754040/
https://ncbi.nlm.nih.gov/pubmed/23804636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01153-13
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