Mutations in the Cytoplasmic Domain of the Newcastle Disease Virus Fusion Protein Confer Hyperfusogenic Phenotypes Modulating Viral Replication and Pathogenicity

The Newcastle disease virus (NDV) fusion protein (F) mediates fusion of viral and host cell membranes and is a major determinant of NDV pathogenicity. In the present study, we demonstrate the effects of functional properties of F cytoplasmic tail (CT) amino acids on virus replication and pathogenesi...

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Bibliographic Details
Main Authors: Samal, Sweety, Khattar, Sunil K., Paldurai, Anandan, Palaniyandi, Senthilkumar, Zhu, Xiaoping, Collins, Peter L., Samal, Siba K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754023/
https://ncbi.nlm.nih.gov/pubmed/23843643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01446-13
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