Oncolytic Vesicular Stomatitis Virus in an Immunocompetent Model of MUC1-Positive or MUC1-Null Pancreatic Ductal Adenocarcinoma

Vesicular stomatitis virus (VSV) is a promising oncolytic agent against various malignancies. Here, for the first time, we tested VSV in vitro and in vivo in a clinically relevant, immunocompetent mouse model of pancreatic ductal adenocarcinoma (PDA). Our system allows the study of virotherapy again...

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Dettagli Bibliografici
Autori principali: Hastie, Eric, Besmer, Dahlia M., Shah, Nirav R., Murphy, Andrea M., Moerdyk-Schauwecker, Megan, Molestina, Carlos, Roy, Lopamudra Das, Curry, Jennifer M., Mukherjee, Pinku, Grdzelishvili, Valery Z.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Gene Delivery
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754007/
https://ncbi.nlm.nih.gov/pubmed/23864625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01412-13
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