Activation of Hypoxia Response in Endothelial Cells Contributes to Ischemic Cardioprotection

Small-molecule inhibition of hypoxia-inducible factor prolyl 4-hydroxylases (HIF-P4Hs) is being explored for the treatment of anemia. Previous studies have suggested that HIF-P4H-2 inhibition may also protect the heart from an ischemic insult. Hif-p4h-2(gt/gt) mice, which have 76 to 93% knockdown of...

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Hauptverfasser: Kerkelä, Risto, Karsikas, Sara, Szabo, Zoltan, Serpi, Raisa, Magga, Johanna, Gao, Erhe, Alitalo, Kari, Anisimov, Andrey, Sormunen, Raija, Pietilä, Ilkka, Vainio, Laura, Koch, Walter J., Kivirikko, Kari I., Myllyharju, Johanna, Koivunen, Peppi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753900/
https://ncbi.nlm.nih.gov/pubmed/23775121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00432-13
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