G-Protein-Coupled Receptor Kinase-5 Mediates Inflammation but Does Not Regulate Cellular Infiltration or Bacterial Load in a Polymicrobial Sepsis Model in Mice

NFκB-dependent signaling is an important modulator of inflammation in several diseases including sepsis. G-protein-coupled receptor kinase-5 (GRK5) is an evolutionarily conserved regulator of the NFκB pathway. We hypothesized that GRK5 via NFκB regulation plays an important role in the pathogenesis...

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Hauptverfasser: Packiriswamy, Nandakumar, Lee, Taehyung, Raghavendra, Pongali B., Durairaj, Haritha, Wang, Hongbing, Parameswaran, Narayanan
Format: Artigo
Sprache:Inglês
Veröffentlicht: S. Karger AG 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753665/
https://ncbi.nlm.nih.gov/pubmed/23485819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000347002
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