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ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy
Anticancer drug therapy activates both molecular cell death and autophagy pathways. Here we show that even sublethal concentrations of DNA-damaging drugs, such as etoposide and cisplatin, induce the expression of autophagy-related protein 5 (ATG5), which is both necessary and sufficient for the subs...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Pub. Group
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3753548/ https://ncbi.nlm.nih.gov/pubmed/23945651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3130 |
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