HIV-1 Vpr Enhances PPARβ/δ-Mediated Transcription, Increases PDK4 Expression, and Reduces PDC Activity

HIV infection and its therapy are associated with disorders of lipid metabolism and bioenergetics. Previous work has suggested that viral protein R (Vpr) may contribute to the development of lipodystrophy and insulin resistance observed in HIV-1–infected patients. In adipocytes, Vpr suppresses mRNA...

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Autors principals: Shrivastav, Shashi, Zhang, Liyan, Okamoto, Koji, Lee, Hewang, Lagranha, Claudia, Abe, Yoshifusa, Balasubramanyam, Ashok, Lopaschuk, Gary D., Kino, Tomoshige, Kopp, Jeffrey B.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2013
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753422/
https://ncbi.nlm.nih.gov/pubmed/23842279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1370
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