Spontaneous Epithelial-Mesenchymal Transition and Resistance to HER-2-Targeted Therapies in HER-2-Positive Luminal Breast Cancer

Resistance to trastuzumab, a rationally designed HER-2-targeting antibody, remains a major hurdle in the management of HER-2-positive breast cancer. Preclinical studies suggest the mechanisms of trastuzumab resistance are numerous. Unfortunately, the majority of these studies are based around HER-2-...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Lesniak, David, Sabri, Siham, Xu, Yaoxian, Graham, Kathryn, Bhatnagar, Pravin, Suresh, Mavanur, Abdulkarim, Bassam
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2013
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753362/
https://ncbi.nlm.nih.gov/pubmed/23991019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071987
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