MGMT modulates glioblastoma angiogenesis and response to the tyrosine kinase inhibitor sunitinib

Angiogenesis inhibitors, such as sunitinib, represent a promising strategy to improve glioblastoma (GBM) tumor response. In this study, we used the O(6)-methylguanine methyltransferase (MGMT)-negative GBM cell line U87MG stably transfected with MGMT (U87/MGMT) to assess whether MGMT expression affec...

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Detalhes bibliográficos
Main Authors: Chahal, Manik, Xu, Yaoxian, Lesniak, David, Graham, Kathryn, Famulski, Konrad, Christensen, James G., Aghi, Manish, Jacques, Amanda, Murray, David, Sabri, Siham, Abdulkarim, Bassam
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940678/
https://ncbi.nlm.nih.gov/pubmed/20179017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq017
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