In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells

α-Synuclein is a small protein strongly implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders. We report here the use of in-cell NMR spectroscopy to observe directly the structure and dynamics of this protein within E. coli cells. To improve the accuracy in th...

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Main Authors: Waudby, Christopher A., Camilloni, Carlo, Fitzpatrick, Anthony W. P., Cabrita, Lisa D., Dobson, Christopher M., Vendruscolo, Michele, Christodoulou, John
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753296/
https://ncbi.nlm.nih.gov/pubmed/23991082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072286
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