Amyloid-beta(1–42) reduces neuronal excitability in mouse dentate gyrus

Amyloid-β (Aβ) is causally implicated in Alzheimer’s disease and neuroplasticity failure has acquired validity as a possible mechanism of early AD pathogenesis. We have previously demonstrated that oligomeric Aβ (1–42) inhibits LTP in the dentate gyrus of rat hippocampal slices. We now show, using w...

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Main Authors: Yun, Sung Hwan, Gamkrelidze, Georgi, Stine, W. Blaine, Sullivan, Patrick M., Pasternak, Joseph F., LaDu, Mary Jo, Trommer, Barbara L.
Format: Artigo
Jezik:Inglês
Izdano: 2006
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752836/
https://ncbi.nlm.nih.gov/pubmed/16765515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2006.04.065
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