Absence of P-selectin in Recipients of Allogeneic Bone Marrow Transplantation Ameliorates Experimental Graft-versus-Host-Disease

Alloreactive T cells are crucial for graft-versus-host-disease (GVHD) pathophysiology, and modulating their trafficking patterns has been efficacious in ameliorating experimental disease. We report here that P-selectin, a glycoprotein found on resting and inflamed endothelium, is important for donor...

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Main Authors: Lu, Sydney X., Holland, Amanda M., Na, Il-Kang, Terwey, Theis H., Alpdogan, Onder, Bautista, Jhoanne L., Smith, Odette M., Suh, David, King, Christopher, Kochman, Adam, Hubbard, Vanessa M., Rao, Uttam K., Yim, Nury, Liu, Chen, Laga, Alvaro C., Murphy, George, Jenq, Robert, Zakrzewski, Johannes L., Penack, Olaf, Dykstra, Lindsay, Bampoe, Kevin, Perez, Lia, Furie, Bruce, Furie, Barbara, van den Brink, Marcel R.M.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752704/
https://ncbi.nlm.nih.gov/pubmed/20622117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903148
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