Enhancement of the mexAB-oprM Efflux Pump Expression by a Quorum-Sensing Autoinducer and Its Cancellation by a Regulator, MexT, of the mexEF-oprN Efflux Pump Operon in Pseudomonas aeruginosa

nfxC-type cells of Pseudomonas aeruginosa that produce the MexEF-OprN efflux pump exhibit resistance to fluoroquinolones and chloramphenicol and hypersusceptibility to most classical β-lactam antibiotics. We investigated the molecular mechanism of how the nfxC mutation causes β-lactam hypersusceptib...

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Main Authors: Maseda, Hideaki, Sawada, Isao, Saito, Kohjiro, Uchiyama, Hiroo, Nakae, Taiji, Nomura, Nobuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC375252/
https://ncbi.nlm.nih.gov/pubmed/15047536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.4.1320-1328.2004
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