UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling

At our body surface, the epidermis absorbs UV radiation. UV overexposure leads to sunburn with tissue injury and pain. To understand how, we focus on TRPV4, a nonselective cation channel highly expressed in epithelial skin cells and known to function in sensory transduction, a property shared with o...

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Detalhes bibliográficos
Main Authors: Moore, Carlene, Cevikbas, Ferda, Pasolli, H. Amalia, Chen, Yong, Kong, Wei, Kempkes, Cordula, Parekh, Puja, Lee, Suk Hee, Kontchou, Nelly-Ange, Yeh, Iwei, Jokerst, Nan Marie, Fuchs, Elaine, Steinhoff, Martin, Liedtke, Wolfgang B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752269/
https://ncbi.nlm.nih.gov/pubmed/23929777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312933110
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