Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1–induced pruritus

In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein–coupled receptor endothelin A receptor (ETAR). Here, we have identified neural...

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Main Authors: Kido-Nakahara, Makiko, Buddenkotte, Jörg, Kempkes, Cordula, Ikoma, Akihiko, Cevikbas, Ferda, Akiyama, Tasuku, Nunes, Frank, Seeliger, Stephan, Hasdemir, Burcu, Mess, Christian, Buhl, Timo, Sulk, Mathias, Müller, Frank-Ulrich, Metze, Dieter, Bunnett, Nigel W., Bhargava, Aditi, Carstens, Earl, Furue, Masutaka, Steinhoff, Martin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038561/
https://ncbi.nlm.nih.gov/pubmed/24812665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67323
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