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Heterogeneity in protein expression induces metabolic variability in a modeled Escherichia coli population

Stochastic gene expression can lead to phenotypic differences among cells even in isogenic populations growing under macroscopically identical conditions. Here, we apply flux balance analysis in investigating the effects of single-cell proteomics data on the metabolic behavior of an in silico Escher...

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Hlavní autoři: Labhsetwar, Piyush, Cole, John Andrew, Roberts, Elijah, Price, Nathan D., Luthey-Schulten, Zaida A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752265/
https://ncbi.nlm.nih.gov/pubmed/23908403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222569110
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