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Composability of regulatory sequences controlling transcription and translation in Escherichia coli

The inability to predict heterologous gene expression levels precisely hinders our ability to engineer biological systems. Using well-characterized regulatory elements offers a potential solution only if such elements behave predictably when combined. We synthesized 12,563 combinations of common pro...

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Main Authors: Kosuri, Sriram, Goodman, Daniel B., Cambray, Guillaume, Mutalik, Vivek K., Gao, Yuan, Arkin, Adam P., Endy, Drew, Church, George M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752251/
https://ncbi.nlm.nih.gov/pubmed/23924614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301301110
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