Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes

IFN regulatory factor (IRF) 3 plays a key role in innate responses against viruses. Herein we assessed its contribution to T-cell activation. We observed that poly(I:C)-induced IRF3 activation in CD8 T cells represses IL-17 expression in a type I IFN-independent fashion. Even in the absence of poly(...

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Autors principals: Ysebrant de Lendonck, Laure, Tonon, Sandrine, Nguyen, Muriel, Vandevenne, Patricia, Welsby, Iain, Martinet, Valerie, Molle, Céline, Charbonnier, Louis-Marie, Leo, Oberdan, Goriely, Stanislas
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752229/
https://ncbi.nlm.nih.gov/pubmed/23918362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219221110
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