Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice

Transgenic mice expressing the mouse interleukin 33 (IL-33) gene driven by a keratin 14 promoter were generated. The skin-selective expression of the IL-33 gene was enhanced, and intense immunofluorescence for IL-33 was evident in the nuclei of the epidermis. Spontaneous itchy dermatitis developed i...

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Autores principales: Imai, Yasutomo, Yasuda, Koubun, Sakaguchi, Yoshiko, Haneda, Takashi, Mizutani, Hitoshi, Yoshimoto, Tomohiro, Nakanishi, Kenji, Yamanishi, Kiyofumi
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752227/
https://ncbi.nlm.nih.gov/pubmed/23918359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307321110
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