Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2

Mechanotransduction in the mammalian auditory system depends on mechanosensitive channels in the hair bundles that project from the apical surface of the sensory hair cells. Individual stereocilia within each bundle contain a core of tightly packed actin filaments, whose length is dynamically regula...

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Detalhes bibliográficos
Main Authors: Furness, David N., Johnson, Stuart L., Manor, Uri, Rüttiger, Lukas, Tocchetti, Arianna, Offenhauser, Nina, Olt, Jennifer, Goodyear, Richard J., Vijayakumar, Sarath, Dai, Yuhai, Hackney, Carole M., Franz, Christoph, Di Fiore, Pier Paolo, Masetto, Sergio, Jones, Sherri M., Knipper, Marlies, Holley, Matthew C., Richardson, Guy P., Kachar, Bechara, Marcotti, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752214/
https://ncbi.nlm.nih.gov/pubmed/23918390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304644110
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