Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies

Antibody cancer therapies rely on systemically accessible targets and suitable antibodies that exert a functional activity or deliver a payload to the tumor site. Here, we present proof-of-principle of in vivo selection of human antibodies in tumor-bearing mice that identified a tumor-specific antib...

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Main Authors: Sánchez-Martín, David, Martínez-Torrecuadrada, Jorge, Teesalu, Tambet, Sugahara, Kazuki N., Alvarez-Cienfuegos, Ana, Ximénez-Embún, Pilar, Fernández-Periáñez, Rodrigo, Martín, M. Teresa, Molina-Privado, Irene, Ruppen-Cañás, Isabel, Blanco-Toribio, Ana, Cañamero, Marta, Cuesta, Ángel M., Compte, Marta, Kremer, Leonor, Bellas, Carmen, Alonso-Camino, Vanesa, Guijarro-Muñoz, Irene, Sanz, Laura, Ruoslahti, Erkki, Alvarez-Vallina, Luis
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752212/
https://ncbi.nlm.nih.gov/pubmed/23918357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300013110
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